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Brescia Bladder Cancer Case-control Study
Study Name: Brescia bladder cancer case-control study
Principal Investigator: Stefano Porru
Additional researchers: Cecilia Arici, Marcello Campagna, Angela Carta, Donatella Placidi, Antonio Scotto di Carlo
Institution: Institute of Occupational Health, University of Brescia, Italy
Institution address: P.le Spedali Civili, 1 25125 Brescia - Italy
Key References:
Hung RJ. et al. Carcinogenesis. 2004 Jun;25(6):973-8.
Hung RJ. et al. Int J Cancer. 2004 Jul 1;110(4):598-604.
Hung RJ. et al. Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):1013-21.
Study Design: Hospital-based case control
Matching factors: Age, gender, and hospital of admission
Country: Italy
ICD-0-3 morphology codes: 8010/2, 8050/3, 8070/3, 8120/2, 8120/3, 8130/2, 8130/3, 8246/3, 8560/3
Follow up of cases? Yes (from 2007)
Expected time of follow-up? 64 -120 months
Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)
| Cases | Controls | |
|---|---|---|
| Years of enrollment | 1997-2000 | 1997-2000 |
| Source population | Province of Brescia | Province of Brescia |
| Response rate (enrolled/eligible) | 93% | 97% |
| Total number enrolled | 216 | 220 |
| Subjects with DNA | 200 | 214 |
| Ethnic origin | 100% Caucasian | 100% Caucasian |
| Age: mean (range) | 63 (22-80) | 63 (22-79) |
| Gender: % males | 100% | 100% |
| Questionnaire data | Cases | Controls |
|---|---|---|
| Demographics (age, sex, ethnicity, region, education etc..) | x | x |
| Active smoking | x | x |
| Passive smoking | x | x |
| Occupational exposures | x | x |
| Residential history | x | x |
| Water chlorination byproducts | x | x |
| Arsenic exposure | - | - |
| Other environmental exposures | x | x |
| Hair dye use | x | - |
| Drug use | x | - |
| Medical History | x | - |
| Family History | - | - |
| Quality of life | - | - |
| Diet/nutrition | x | x |
| Caffeine intake | x | x |
| Fluid intake | x | x |
| Urine pH measurements | - | - |
| Other information, please specify | x | x |
| Biological Samples | Cases | Controls |
|---|---|---|
| Blood DNA | x | x |
| Buccal DNA | - | - |
| Serum/plasma | x | x |
| Cryopreserved whole blood / lymphocytes | x | x |
| Red blood cells | x | x |
| Urine samples | - | - |
| Toenail clippings | - | - |
| Others, please specify | - | - |
| Paraffin tissue blocks | - | |
| Frozen tissue | - |
| For Cases Only | |
| Information at time of diagnosis | Cases |
|---|---|
| Histological confirmation | x |
| Number of tumors | x |
| Tumor site | x |
| Tumor size | - |
| Tumor grade | x |
| Growth pattern | x |
| Treatment of primary tumor | x |
| Stage | x |
| Other information, please specify | - |
| Follow-up information | Cases |
|---|---|
| Treatment information | x |
| Tumor recurrence | x |
| Tumor progression | x |
| Survival | x |
| Histological confirmation | x |
| Number of tumors | x |
| Tumor site | x |
| Tumor size | x |
| Tumor grade | x |
| Growth pattern | x |
| Stage | x |
| Active smoking | x |
| Occupational exposures | x |
| Drug use | x |
| Medical History | x |
| Quality of life | - |
| Caffeine intake | x |
| Fluid intake | x |
| Other information , please specify | x |