Eastern European Bladder Cancer Study

Study Name: Eastern European Bladder Cancer Study

Principal Investigators: Tony Fletcher

Additional researchers:

Institution: PEHRU Public and Environmental Health Research Unit, London School of Hygiene & Tropical Medicine

Institution address:
PEHRU Public and Environmental Health Research Unit,\
London School of Hygiene & Tropical Medicine
Keppel Street
London WC1E 7HT, UK

Key References: 

Study Design: Hospital-based case control

Matching factors: Age, gender

Country: Hungary, Romania, Slovakia

ICD-0-3 morphology codes:  

Follow up of cases? No

Expected time of follow-up? NA

Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)

  Cases Controls
Years of enrollment 2002-2004 2002-2004
Source population Hungary, Romania and Slovakia Hungary, Romania and Slovakia
Response rate (enrolled/eligible) 85.3%  
Total number enrolled 214 540
Subjects with DNA 214 540
Ethnic origin Caucasian Caucasian
Age: mean (range) 30-79 30-79
Gender: % males    
Questionnaire data Cases Controls
Demographics (age, sex, ethnicity, region, education etc..) x x
Active smoking x x
Passive smoking x x
Occupational exposures x x
Residential history x x
Water chlorination byproducts - -
Arsenic exposure x x
Other environmental exposures - -
Hair dye use - -
Drug use x x
Medical History x x
Family History x x
Quality of life - -
Diet/nutrition x x
Caffeine intake x x
Fluid intake x x
Urine pH measurements - -
Other information, please specify x x
Biological Samples Cases Controls
Blood DNA x x
Buccal DNA x x
Serum/plasma - -
Cryopreserved whole blood / lymphocytes - -
Red blood cells - -
Urine samples - -
Toenail clippings - -
Others, please specify - -
Paraffin tissue blocks -
Frozen tissue -
For Cases Only
Information at time of diagnosis Cases
Histological confirmation x
Number of tumors -
Tumor site -
Tumor size -
Tumor grade x
Growth pattern -
Treatment of primary tumor -
Stage -
Other information, please specify -
Follow-up information Cases
Treatment information -
Tumor recurrence -
Tumor progression -
Survival -
Histological confirmation -
Number of tumors -
Tumor site -
Tumor size -
Tumor grade -
Growth pattern -
Stage -
Active smoking -
Occupational exposures -
Drug use -
Medical History -
Quality of life -
Caffeine intake -
Fluid intake -
Other information , please specify -