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A Genotype-Phenotype Urothelial Cancer Study
Study Name: A Genotype-Phenotype Urothelial Cancer Study
Principal Investigators:
Dean Bajorin
Kenneth Offit
Additional researchers:
Mia Gaudet
David Gallagher
Robert Hamilton
Institution/s:
Memorial Sloan-Kettering Cancer Center
Institution/s address:
Memorial Sloan-Kettering Cancer Center
1275 York Ave New York, NY, 10065
Phone: 646 888 4067
Key References: None as yet
Study Design: Hospital Based Case-controll
Matching factors: Age, sex, race
Country: USA
ICD-0-3 morphology codes: all below codes
Follow up of cases? Yes
Expected time of follow-up? 1yr questionnaire; on-going clinical
Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903);
| Cases | Controls | |
|---|---|---|
| Years of enrollment | May 2009-present | May 2009-present |
| Source population | MSKCC oncology and urology outpatient clinics |
Genetically unrelated people accompanying cases to clinic; patients presenting to MSKCC clinics without any cancer history |
| Response rate (enrolled/eligible) | NA | NA |
| Total number enrolled | 840 | 344 |
| Subjects with DNA | 840 | 344 |
| Ethnic origin | Mixed | Mixed |
| Age: mean (range) | 68 (22-96) | 62 (23-88) |
| Gender: % males | 76% | 31% |
| Questionnaire data | Cases | Controls |
|---|---|---|
| Demographics (age, sex, ethnicity, region, education etc..) | x | x |
| Active smoking | x | x |
| Passive smoking | x | x |
| Occupational exposures | x | x |
| Residential history | - | - |
| Water chlorination byproducts | - | - |
| Arsenic exposure | - | - |
| Other environmental exposures | - | - |
| Hair dye use | x | x |
| Drug use | x | x |
| Medical History | x | x-partial |
| Family History | x | - |
| Quality of life | - | - |
| Diet/nutrition | - | - |
| Caffeine intake | x | x |
| Fluid intake | x | x |
| Urine pH measurements | - | - |
| Other information, please specify | - | - |
| Biological Samples | Cases | Controls |
|---|---|---|
| Blood DNA | - | - |
| Buccal DNA | x | x |
| Serum/plasma | - | - |
| Cryopreserved whole blood / lymphocytes | - | - |
| Red blood cells | - | - |
| Urine samples | - | - |
| Toenail clippings | - | - |
| Others, please specify | - | - |
| Paraffin tissue blocks | x | |
| Frozen tissue | x (some) |
| For Cases Only Note: Approximately half of our patients are classified as superficial disease, and some more data is collected on them (indicated by "S" below) |
|
| Information at time of diagnosis | Cases |
|---|---|
| Histological confirmation | x |
| Number of tumors | - |
| Tumor site | x |
| Tumor size | - |
| Tumor grade | x |
| Growth pattern | - |
| Treatment of primary tumor | x |
| Stage | x |
| Other information, please specify | - |
| Follow-up information | Cases |
|---|---|
| Treatment information | x |
| Tumor recurrence | x |
| Tumor progression | s |
| Survival | x |
| Histological confirmation | s |
| Number of tumors | x |
| Tumor site | x |
| Tumor size | s |
| Tumor grade | s |
| Growth pattern | s |
| Stage | s |
| Active smoking | x |
| Occupational exposures | - |
| Drug use | - |
| Medical History | x |
| Quality of life | - |
| Caffeine intake | - |
| Fluid intake | - |
| Other information , please specify | - |