The Los Angeles-Shanghai Bladder Cancer Study
Study Name: The Los Angeles-Shanghai Bladder Cancer Study
Principal Investigators: Ronald K. Ross (deceased, now Malcolm C. Pike) USC
Additional researchers:
University of Minnesota: Mimi C. Yu
USC: J. Esteban Castelao, David Conti,
Victoria Cortessis, Manuela Gago-Dominguez,
Mariana Stern, Duncan Thomas,
David Van Den Berg
Institution/s:
USC/Norris Comprehensive Cancer Center
University of Minnesota Cancer Center
Institution/s address:
USC/Norris Cancer Center
1441 Eastlake Avenue
Los Angeles, California 90089
University of Minnesota Cancer Center
1300 South Second Street, Suite 300
Minneapolis, Minnesota 55454
Key References:
(1) Int J Cancer 2004 110: 417;
(2) Carcinogenesis 2003 24: 1645;
(3) Eur J Epidemiol 2003 18: 659;
(4) CEBP 2003 12: 503;
(5) Carcinogenesis 24: 483-489, 2003;
(6) J Natl Cancer Inst 2001 93: 538;
(7) Int J Cancer 2001 91 575;
(8) Br J Cancer 2000 82: 1364.
Study Design: Population based Case- Control
Matching factors: Age, gender, sex
Country: United States and China
ICD-0-3 morphology codes: -
Follow up of cases? -
Expected time of follow-up? -
Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)
Cases | Controls | |
---|---|---|
Years of enrollment | LA: 1988-1999 Shanghai: 1996-1999 |
LA: 1988-1999 Shanghai: 1996-1999 |
Source population | LA: non-Asian
residents of Los
Angeles County,
California Shanghai: Han Chinese residents of city of Shanghai |
LA: non-Asian
residents of Los
Angeles County,
California Shanghai: Han Chinese residents of city of Shanghai |
Response rate (enrolled/eligible) | LA: 70% (1671/2384) Shanghai: 83% (622/749) |
LA: 69% 1st and 31%
≥2nd eligible controls Shanghai: 84% |
Total number enrolled | LA: 1671 Shanghai: 622 |
LA: 1568 Shanghai: 610 |
Subjects with DNA | LA: 723 Shanghai: 545 |
LA: 760 Shanghai: 537 |
Ethnic origin | LA: 92.3% non-
Hispanic white 4.3% Hispanic white 3.3% African American 0.1% Native American Shanghai: Han Chinese |
|
Age: mean (range) | LA: 56 (25-69) Shanghai: |
LA: 56 (25-69) Shanghai: |
Gender: % males | LA: 78.6% Shanghai: 79% |
LA: 78.0% Shanghai: 77% |
Questionnaire data | Cases | Controls |
---|---|---|
Demographics (age, sex, ethnicity, region, education etc..) | x | x |
Active smoking | x | x |
Passive smoking | x | x |
Occupational exposures | x | x |
Residential history | - | - |
Water chlorination byproducts | - | - |
Arsenic exposure | - | - |
Other environmental exposures | x | x |
Hair dye use | x | x |
Drug use | x | x |
Medical History | x | x |
Family History | x | x |
Quality of life | - | - |
Diet/nutrition | x | x |
Caffeine intake | x | x |
Fluid intake | x | x |
Urine pH measurements | x | x |
Other information, please specify | x | x |
Biological Samples | Cases | Controls |
---|---|---|
Blood DNA | x | x |
Buccal DNA | - | - |
Serum/plasma | x | x |
Cryopreserved whole blood / lymphocytes | - | - |
Red blood cells | x | x |
Urine samples | x | x |
Toenail clippings | - | - |
Others, please specify | - | - |
Paraffin tissue blocks | x | |
Frozen tissue | - |
For Cases Only | |
Information at time of diagnosis | Cases |
---|---|
Histological confirmation | - |
Number of tumors | - |
Tumor site | - |
Tumor size | - |
Tumor grade | - |
Growth pattern | - |
Treatment of primary tumor | - |
Stage | - |
Other information, please specify | - |
Follow-up information | Cases |
---|---|
Treatment information | - |
Tumor recurrence | - |
Tumor progression | - |
Survival | - |
Histological confirmation | - |
Number of tumors | - |
Tumor site | - |
Tumor size | - |
Tumor grade | - |
Growth pattern | - |
Stage | - |
Active smoking | - |
Occupational exposures | - |
Drug use | - |
Medical History | - |
Quality of life | - |
Caffeine intake | - |
Fluid intake | - |
Other information , please specify | - |