The Los Angeles-Shanghai Bladder Cancer Study

Study Name: The Los Angeles-Shanghai Bladder Cancer Study

Principal Investigators: Ronald K. Ross (deceased, now Malcolm C. Pike) USC

Additional researchers:
University of Minnesota: Mimi C. Yu
USC: J. Esteban Castelao, David Conti, Victoria Cortessis, Manuela Gago-Dominguez, Mariana Stern, Duncan Thomas, David Van Den Berg

Institution/s:
USC/Norris Comprehensive Cancer Center
University of Minnesota Cancer Center

Institution/s address:
USC/Norris Cancer Center
1441 Eastlake Avenue
Los Angeles, California 90089

University of Minnesota Cancer Center
1300 South Second Street, Suite 300
Minneapolis, Minnesota 55454

Key References: 
(1) Int J Cancer 2004 110: 417;
(2) Carcinogenesis 2003 24: 1645;
(3) Eur J Epidemiol 2003 18: 659;
(4) CEBP 2003 12: 503;
(5) Carcinogenesis 24: 483-489, 2003;
(6) J Natl Cancer Inst 2001 93: 538;
(7) Int J Cancer 2001 91 575;
(8) Br J Cancer 2000 82: 1364.

Study Design: Population based Case- Control

Matching factors: Age, gender, sex

Country: United States and China

ICD-0-3 morphology codes: -

Follow up of cases? -

Expected time of follow-up? -

Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)

  Cases Controls
Years of enrollment LA: 1988-1999
Shanghai: 1996-1999		 LA: 1988-1999
Shanghai: 1996-1999
Source population LA: non-Asian residents of Los Angeles County, California
Shanghai: Han Chinese residents of city of Shanghai		 LA: non-Asian residents of Los Angeles County, California
Shanghai: Han Chinese residents of city of Shanghai
Response rate (enrolled/eligible) LA: 70% (1671/2384)
Shanghai: 83% (622/749)		 LA: 69% 1st and 31% ≥2nd eligible controls
Shanghai: 84%
Total number enrolled LA: 1671
Shanghai: 622		 LA: 1568
Shanghai: 610
Subjects with DNA LA: 723
Shanghai: 545		 LA: 760
Shanghai: 537
Ethnic origin LA: 92.3% non- Hispanic white
4.3% Hispanic white
3.3% African American
0.1% Native American
Shanghai: Han Chinese		  
Age: mean (range) LA: 56 (25-69)
Shanghai:		 LA: 56 (25-69)
Shanghai:
Gender: % males LA: 78.6%
Shanghai: 79%		 LA: 78.0%
Shanghai: 77%
Questionnaire data Cases Controls
Demographics (age, sex, ethnicity, region, education etc..) x x
Active smoking x x
Passive smoking x x
Occupational exposures x x
Residential history - -
Water chlorination byproducts - -
Arsenic exposure - -
Other environmental exposures x x
Hair dye use x x
Drug use x x
Medical History x x
Family History x x
Quality of life - -
Diet/nutrition x x
Caffeine intake x x
Fluid intake x x
Urine pH measurements x x
Other information, please specify x x
Biological Samples Cases Controls
Blood DNA x x
Buccal DNA - -
Serum/plasma x x
Cryopreserved whole blood / lymphocytes - -
Red blood cells x x
Urine samples x x
Toenail clippings - -
Others, please specify - -
Paraffin tissue blocks x
Frozen tissue -
For Cases Only
Information at time of diagnosis Cases
Histological confirmation -
Number of tumors -
Tumor site -
Tumor size -
Tumor grade -
Growth pattern -
Treatment of primary tumor -
Stage -
Other information, please specify -
Follow-up information Cases
Treatment information -
Tumor recurrence -
Tumor progression -
Survival -
Histological confirmation -
Number of tumors -
Tumor site -
Tumor size -
Tumor grade -
Growth pattern -
Stage -
Active smoking -
Occupational exposures -
Drug use -
Medical History -
Quality of life -
Caffeine intake -
Fluid intake -
Other information , please specify -