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Leeds Bladder Cancer Study
Study Name: Leeds Bladder Cancer Study (Molecular Epidemiology of DNA repair and Bladder Cancer)
Principal Investigators: Anne Kiltie, Clinical Group Leader/Honorary Consultant Clinical Oncologist
Additional researchers:
D Tim Bishop, CR-UK
Jennifer H Barrett, CR-UK
Sei Chung Sak, now NHS
Alan B Paul, NHS
Institution: Gray Institute for Radiation Oncology and Biology
Institution address:
Old Road Campus Research Building
Off Roosevelt Drive
OXFORD OX3 7DQ
Key References:
Sak SC, Barrett J, Paul A, Bishop DT, Kiltie AE (2005)
British Journal of Cancer 92:2262-2265.
Sak SC, Barrett JH, Paul AB, Bishop DT, Kiltie AE (2006)
Cancer Epidemiology Biomarkers and Prevention 15:2537-41.
Study Design: Hospital-based case control
Matching factors: Age and gender
Country: UK
ICD-0-3 morphology codes: 81203
Follow up of cases? Yes
Expected time of follow-up? Currently 3-5 years
Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)
| Cases | Controls | |
|---|---|---|
| Years of enrollment | 2002-ongoing | 2002-2004 |
| Source population | County of West Yorkshire UK | County of West Yorkshire UK |
| Response rate (enrolled/eligible) | 900/1100 | Approx 80% |
| Total number enrolled | 1100 | 900 |
| Subjects with DNA | 1100 | 900 |
| Ethnic origin | 98.5% Caucasian | 98.5% Caucasian |
| Age: mean (range) | 72.8 | 71.9 |
| Gender: % males | 71% | 65% |
| Questionnaire data | Cases | Controls |
|---|---|---|
| Demographics (age, sex, ethnicity, region, education etc..) | x | x |
| Active smoking | x | x |
| Passive smoking | - | - |
| Occupational exposures | x | x |
| Residential history | x | x |
| Water chlorination byproducts | - | - |
| Arsenic exposure | - | - |
| Other environmental exposures | - | - |
| Hair dye use | - | - |
| Drug use | - | - |
| Medical History | - | - |
| Family History | x | x |
| Quality of life | - | - |
| Diet/nutrition | - | - |
| Caffeine intake | - | - |
| Fluid intake | - | - |
| Urine pH measurements | - | - |
| Other information, please specify | - | - |
| Biological Samples | Cases | Controls |
|---|---|---|
| Blood DNA | x | x |
| Buccal DNA | - | - |
| Serum/plasma | - | - |
| Cryopreserved whole blood / lymphocytes | - | - |
| Red blood cells | - | - |
| Urine samples | - | - |
| Toenail clippings | - | - |
| Others, please specify | - | - |
| Paraffin tissue blocks | x | |
| Frozen tissue | - |
| For Cases Only | |
| Information at time of diagnosis | Cases |
|---|---|
| Histological confirmation | x |
| Number of tumors | x |
| Tumor site | x |
| Tumor size | x |
| Tumor grade | x |
| Growth pattern | x |
| Treatment of primary tumor | x |
| Stage | x |
| Other information, please specify | - |
| Follow-up information | Cases |
|---|---|
| Treatment information | x |
| Tumor recurrence | x |
| Tumor progression | x |
| Survival | x |
| Histological confirmation | x |
| Number of tumors | x |
| Tumor site | x |
| Tumor size | x |
| Tumor grade | x |
| Growth pattern | x |
| Stage | x |
| Active smoking | x |
| Occupational exposures | x |
| Drug use | x |
| Medical History | x |
| Quality of life | - |
| Caffeine intake | - |
| Fluid intake | - |
| Other information , please specify | - |