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Lutherstadt Wittenberg Bladder Cancer Study
Study Name: Lutherstadt Wittenberg Bladder Cancer Study (LWBCS)
Principal Investigators: Klaus Golka, Jan G. Hengstler
Additional researchers:
Silvia Selinski, IfADo
Meinolf Blaszkewicz, IfADo
Matthias Hermes, IfADO
Institution: Leibniz Research Centre for Working Environment and Human Factors (IfADo)
Institution address:
IfADo Ardeystr. 67
44139 Dortmund
Germany
Tel: +49 231 1084 344
Fax: +49 231 1084 308
Key References:
Golka K. et al: J. Toxicol. Environ. Health Part A 2008 71:881-6
Zimmermann A. et al: J. Toxicol. Environ. Health Part A 2008 71:911-4
Study Design: Hospital based Case-Control
Matching factors: Gender, age, hospital
Country: Germany
ICD-0-3 morphology codes: Transitional cell carcinoma (according to ICD 10)
Follow up of cases? Yes
Expected time of follow-up? At least 114 months
Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)
| Cases | Controls | |
|---|---|---|
| Years of enrollment | Dec 1995-Jan 1999 | Jul 2000-Apr 2005 |
| Source population | 1 hospital | 1 hospital |
| Response rate (enrolled/eligible) | ||
| Total number enrolled | ||
| Subjects with DNA | 216 | 211 |
| Ethnic origin | German | German |
| Age: mean (range) | 67 (20-93) | 67 (29-91) |
| Gender: % males | 186 | 175 |
| Questionnaire data | Cases | Controls |
|---|---|---|
| Demographics (age, sex, ethnicity, region, etc..) | x | x |
| Active smoking | x | x |
| Passive smoking (only for non smokers-ex smokers) | - | - |
| Occupational exposures | x | x |
| Residential history | - | - |
| Water chlorination byproducts | - | - |
| Arsenic exposure | - | - |
| Other environmental exposures | - | - |
| Hair dye use | - | - |
| Drug use (available for pain killers only) | x | x |
| Medical History | - | - |
| Family History (related to bladder cancer) | x | x |
| Quality of life | - | - |
| Diet/nutrition | - | - |
| Caffeine intake | - | - |
| Fluid intake | - | - |
| Urine pH measurements | - | - |
| Other information, please specify (alcohol, tea, soft drinks; diuresis) |
| Biological Samples | Cases | Controls |
|---|---|---|
| Blood DNA | x | x |
| Buccal DNA | - | - |
| Serum/plasma | - | - |
| Cryopreserved whole blood / lymphocytes | - | - |
| Red blood cells | - | - |
| Urine samples | - | - |
| Toenail clippings | - | - |
| Others, please specify | - | - |
| Paraffin tissue blocks | Asked | |
| Frozen tissue | - |
| For Cases Only | |
| Information at time of diagnosis | Cases |
|---|---|
| Histological confirmation | x |
| Number of tumors (available after follow up) | - |
| Tumor site | - |
| Tumor size | - |
| Tumor grade | x |
| Growth pattern | - |
| Treatment of primary tumor | x |
| Stage | x |
| Other information, please specify | - |
| Follow-up information | Cases |
|---|---|
| Treatment information | x |
| Tumor recurrence (available after follow up) | x |
| Tumor progression (available after follow up) | x |
| Survival (available after follow up) | x |
| Histological confirmation | x |
| Number of tumors | - |
| Tumor site | - |
| Tumor size | - |
| Tumor grade | x |
| Growth pattern | - |
| Stage | x |
| Active smoking | - |
| Occupational exposures | - |
| Drug use | - |
| Medical History | - |
| Quality of life | - |
| Caffeine intake | - |
| Fluid intake | - |
| Other information, please specify (as above) | - |