An official website of the United States government
M.D. Anderson Bladder Cancer Study
Study Name: M.D. Anderson Bladder Cancer Study
Principal Investigators: Xifeng Wu
Additional researchers:
Institution: The University of Texas M. D. Anderson Cancer Center
Institution address: 1515 Holcombe Blvd, Houston, TX 77030
Key References:
Wu X. et al. 2009 Nat Genet. 41 (9) 991-5.
Wu X. et al. 2007. J Clin Oncol. 25 (31): 4974-81.
Study Design: Hospital based Case-Control
Matching factors: Age, gender, ethnicity
Country: USA
ICD-0-3 morphology codes: 189.8
Follow up of cases? Yes
Expected time of follow-up?
Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)
| Cases | Controls | |
|---|---|---|
| Years of enrollment | 1999-2009 | 1999-2009 |
| Source population | M.D. Anderson Hospital | Houston Metropolitan Area |
| Response rate (enrolled/eligible) | 92% | 77% |
| Total number enrolled | 1542 | 1610 |
| Subjects with DNA | 1542 | 1610 |
| Ethnic origin | Caucasian 91.8% Hispanic 3.8% African American 3.5% Other 0.9% |
Matched to cases |
| Age: mean (range) | 63.4 (18-89) | 62.5 (21-89) |
| Gender: % males | 79.1% | 77.4% |
| Questionnaire data | Cases | Controls |
|---|---|---|
| Demographics (age, sex, ethnicity, region, education etc..) | x | x |
| Active smoking | x | x |
| Passive smoking | x | x |
| Occupational exposures | x | x |
| Residential history | - | - |
| Water chlorination byproducts | - | - |
| Arsenic exposure | - | - |
| Other environmental exposures | x | x |
| Hair dye use | x | x |
| Drug use | - | - |
| Medical History | x | x |
| Family History | x | x |
| Quality of life | - | - |
| Diet/nutrition | x | x |
| Caffeine intake | - | - |
| Fluid intake | x | x |
| Urine pH measurements | - | - |
| Other information, please specify | - | - |
| Biological Samples | Cases | Controls |
|---|---|---|
| Blood DNA | x | x |
| Buccal DNA | - | - |
| Serum/plasma | x | x |
| Cryopreserved whole blood / lymphocytes | - | - |
| Red blood cells | - | - |
| Urine samples | - | - |
| Toenail clippings | - | - |
| Others, please specify | - | - |
| Paraffin tissue blocks | - | |
| Frozen tissue | - |
| For Cases Only | |
| Information at time of diagnosis | Cases |
|---|---|
| Histological confirmation | x |
| Number of tumors | - |
| Tumor site | - |
| Tumor size | x |
| Tumor grade | x |
| Growth pattern | - |
| Treatment of primary tumor | x |
| Stage | x |
| Other information, please specify | - |
| Follow-up information | Cases |
|---|---|
| Treatment information | x |
| Tumor recurrence | x |
| Tumor progression | x |
| Survival | x |
| Histological confirmation | x |
| Number of tumors | x |
| Tumor site | - |
| Tumor size | x |
| Tumor grade | x |
| Growth pattern | - |
| Stage | x |
| Active smoking | x |
| Occupational exposures | x |
| Drug use | - |
| Medical History | x |
| Quality of life | - |
| Caffeine intake | - |
| Fluid intake | x |
| Other information , please specify | - |