An official website of the United States government
New England Bladder Cancer Study
Study Name: New England Bladder Cancer Study
Principal Investigators:
NCI-DCEG: Debra Silverman, Dalsu Baris
Dartmouth Medical School: Margaret Karagas, Richard Wadell
Department of Health and Human Services, Maine Cancer Registry: Molly Schwenn
VT Cancer Registry: Alison Johnson
Additional researchers:
Angeline Andrew (Dartmouth Medical School)
Bill Apao (Vermont)
Laura Beane-Freeman (NCI)
Ken Cantor (NCI, Lead Investigator)
Sai Cherala (New Hampshire)
Montserrat Garcia-Closas (NCI)
Joanne Colt (NCI, Lead Investigator)
Jay Lubin (NCI)
Lee Moore (NCI)
Nathaniel Rothman (NCI, Lead Investigator)
Alan Schned (Dartmouth Medical School)
Castine Verrill (Maine)
Institution/s:
National Cancer Institute Division of Cancer Epidemiology and Genetics (NCI-DCEG)
Dartmouth Medical School
New Hampshire Department of Health and Human Services
Maine Department of Health and Human Services
Vermont Cancer Registry
Institution/s address:
NCI-DCEG
6120 Executive Boulevard
Bethesda, MD USA 20852-7234
Dartmouth Medical School
7927 Rubin Building
One Medical Center Drive
Lebanon, NH 03756
Department of Health and Human Services
Maine Cancer Registry
Key Bank Plaza
4th Floor Augusta, ME 04333
VT Cancer Registry
108 Cherry Street
Burlington, VT 05401
Key References:
Baris D. et al. J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61. Epub 2009 Nov 16.
Colt JS, et al. Occup Environ Med. 2010 Sep 23. [Epub ahead of print]
Moore L, et al. Carcinogenesis. 2010 Oct 29. [Epub ahead of print]
Study Design: Population based Case-Control
Matching factors: age and sex
Country: USA
ICD-9 code: 189.8
ICD-0-3 morphology codes:7400/6, 7400/7, 8010/2, 8032/3, 8041/3, 8053/0, 8070/3, 8120/3, 8130/3, 8140/3
Follow up of cases? Feasibility
study is being initiated
Expected time of follow-up?
Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)
| Cases | Controls | |
|---|---|---|
| Years of enrollment | 2001-2004 | 2001-2004 |
| Source population | Newly diagnosed incident cases in the states of New Hampshire, Maine and Vermon | Frequency matched controls selected from Department of Motor Vehicle (<65 years of age) and Centers of Medicare and Medicaid Services (>=65 years of age) |
| Response rate (enrolled/eligible) | 65% | 65% |
| Total number enrolled | 1,213 | 1,418 |
| Subjects with DNA | 1,134 | 1,306 |
| Ethnic origin | 94% Caucasian | 94% Caucasian |
| Age: mean (range) | 65.16 (30-79) | 64.52 (30-79) |
| Gender: % males | 76% | 73% |
| Questionnaire data | Cases | Controls |
|---|---|---|
| Demographics (age, sex, ethnicity, region, education etc..) | x | x |
| Active smoking | x | x |
| Passive smoking | x | x |
| Occupational exposures | x | x |
| Residential history | x | x |
| Water chlorination byproducts | x | x |
| Arsenic exposure | x | x |
| Other environmental exposures | x | x |
| Hair dye use | x | x |
| Drug use | x | x |
| Medical History | x | x |
| Family History | x | x |
| Quality of life | - | - |
| Diet/nutrition | x | x |
| Caffeine intake | x | x |
| Fluid intake | x | x |
| Urine pH measurements | x | x |
| Other information, please specify | - | - |
| Biological Samples | Cases | Controls |
|---|---|---|
| Blood DNA | x | x |
| Buccal DNA | x | x |
| Serum/plasma | x | x |
| Cryopreserved whole blood / lymphocytes | x | x |
| Red blood cells | x | x |
| Urine samples | x | x |
| Toenail clippings | x | x |
| Others, please specify | - | - |
| Paraffin tissue blocks | x | |
| Frozen tissue | - |
| For Cases Only | |
| Information at time of diagnosis | Cases |
|---|---|
| Histological confirmation | x |
| Number of tumors | x |
| Tumor site | x |
| Tumor size | x |
| Tumor grade | x |
| Growth pattern | x |
| Treatment of primary tumor | - |
| Stage | x |
| Other information, please specify | - |
| Follow-up information | Cases |
|---|---|
| Treatment information | - |
| Tumor recurrence | - |
| Tumor progression | - |
| Survival | - |
| Histological confirmation | - |
| Number of tumors | - |
| Tumor site | - |
| Tumor size | - |
| Tumor grade | - |
| Growth pattern | - |
| Stage | - |
| Active smoking | - |
| Occupational exposures | - |
| Drug use | - |
| Medical History | - |
| Quality of life | - |
| Caffeine intake | - |
| Fluid intake | - |
| Other information , please specify (as above) | - |