New Hampshire Bladder Cancer Study

Study Name: New Hampshire Bladder Cancer Study

Principal Investigators: Margaret R Karagas

Additional researchers:
Alan Schned
Karl Kelsey
Angeline Andrew
Carmin Marsit

Institution: Dartmouth Medical School Section of biostatistics and epidemiology

Institution address:
7927 Rubin Building
One Medical Center Drive
Lebanon, NH 03756

Key References: 
Karagas MR. et al. Environ Health Perspect. 1998 Aug;106 Suppl 4:1047-50.
Danaee H. et al. Oncogene. 2002 Jul 25;21(32):4894-9.
Andrew AS. et al. Int J Cancer. 2004 Apr 20;109(4):581-6.

Study Design: Population based Case- Control

Matching factors: None

Country: USA

ICD-0-3 morphology codes: All

Follow up of cases? Yes

Expected time of follow-up? 5-15 years or longer

Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)

	Cases	Controls
Years of enrollment	1994-2001	1994-2001
Source population	New Hampshire USA	New Hampshire USA
Response rate (enrolled/eligible)	85%	70%
Total number enrolled	847	1091
Subjects with DNA	728	995
Ethnic origin	>90% White, Non- Hispanic
Age: mean (range)	62	61
Gender: % males	84%	76%

Questionnaire data	Cases	Controls
Demographics (age, sex, ethnicity, region, education etc..)	x	x
Active smoking	x	x
Passive smoking	x	x
Occupational exposures	x	x
Residential history	x	x
Water chlorination byproducts	x	x
Arsenic exposure	x	x
Other environmental exposures	x	x
Hair dye use	x	x
Drug use	x	x
Medical History	x	x
Family History	x	x
Quality of life	-	-
Diet/nutrition	x	x
Caffeine intake	x	x
Fluid intake	x	x
Urine pH measurements	-	-
Other information, please specify	-	-

Biological Samples	Cases	Controls
Blood DNA	x	x
Buccal DNA	x	x
Serum/plasma	x	x
Cryopreserved whole blood / lymphocytes	x	x
Red blood cells	x	x
Urine samples	-	x
Toenail clippings	x	x
Others, please specify	-	-
Paraffin tissue blocks	x
Frozen tissue	-

For Cases Only
Information at time of diagnosis	Cases
Histological confirmation	x
Number of tumors	x
Tumor site	x
Tumor size	x
Tumor grade	x
Growth pattern	x
Treatment of primary tumor	x
Stage	x
Other information, please specify	x

Follow-up information	Cases
Treatment information	x
Tumor recurrence	x
Tumor progression	x
Survival	x
Histological confirmation	x
Number of tumors	x
Tumor site	x
Tumor size	x
Tumor grade	x
Growth pattern	-
Stage	x
Active smoking	x
Occupational exposures	-
Drug use	x
Medical History	x
Quality of life	-
Caffeine intake	-
Fluid intake	-
Other information , please specify	x