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The South and East China case control study on Bladder Cancer. SEarCh
Study Name: The South and East China case control study on Bladder Cancer. SEarCh
Principal Investigator: Maurice Zeegers
Additional researchers: Marjolein Hemelt
Institution:
Department of Public Health and Epidemiology University of Birmingham, UK
Institution addresses:
Unit of Genetic Epidemiology
Department of Public Health and Epidemiology
University of Birmingham, Public Health Building
Edgbaston, Birmingham, B15 2TT England
Key References:
Study Design: Hospital-based case control
Matching factors: Frequency matched on age, sex, hospital
Country: China
ICD-0-3 morphology codes: 801203, 81303, 80703
Follow up of cases? No
Expected time of follow-up?
Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)
| Cases | Controls | |
|---|---|---|
| Years of enrollment | 2005-continuing | 2005-continuing |
| Source population | 4 hospitals in 4 cities in China | 4 hospitals in 4 cities in China |
| Response rate (enrolled/eligible) | 95% | 95% |
| Total number enrolled | 225/yr | 225/yr |
| Subjects with DNA | 95% | 95% |
| Ethnic origin | Asian | Asian |
| Age: mean (range) | 70, 30-93 | 70, 30-93 |
| Gender: % males | 80% | 80% |
| Questionnaire data | Cases | Controls |
|---|---|---|
| Demographics (age, sex, ethnicity, region, education etc..) | x | x |
| Active smoking | x | x |
| Passive smoking | x | x |
| Occupational exposures | x | x |
| Residential history | - | - |
| Water chlorination byproducts | - | - |
| Arsenic exposure | - | - |
| Other environmental exposures | - | - |
| Hair dye use | x | x |
| Drug use | x | x |
| Medical History | x | x |
| Family History | x | x |
| Quality of life | - | - |
| Diet/nutrition | x | x |
| Caffeine intake | x | x |
| Fluid intake | x | x |
| Urine pH measurements | - | - |
| Other information, please specify | - | - |
| Biological Samples | Cases | Controls |
|---|---|---|
| Blood DNA | - | - |
| Buccal DNA | x | x |
| Serum/plasma | - | - |
| Cryopreserved whole blood / lymphocytes | - | - |
| Red blood cells | - | - |
| Urine samples | - | - |
| Toenail clippings | x | x |
| Others, please specify | - | - |
| Paraffin tissue blocks | - | |
| Frozen tissue | - |
| For Cases Only | |
| Information at time of diagnosis | Cases |
|---|---|
| Histological confirmation | x |
| Number of tumors | - |
| Tumor site | x |
| Tumor size | - |
| Tumor grade | x |
| Growth pattern | - |
| Treatment of primary tumor | - |
| Stage | x |
| Other information, please specify | - |
| Follow-up information | Cases |
|---|---|
| Treatment information | - |
| Tumor recurrence | - |
| Tumor progression | - |
| Survival | - |
| Histological confirmation | - |
| Number of tumors | - |
| Tumor site | - |
| Tumor size | - |
| Tumor grade | - |
| Growth pattern | - |
| Stage | - |
| Active smoking | - |
| Occupational exposures | - |
| Drug use | - |
| Medical History | - |
| Quality of life | - |
| Caffeine intake | - |
| Fluid intake | - |
| Other information , please specify | - |