An official website of the United States government
UCLA Molecular Epidemiology of Bladder Cancer
Study Name: Molecular Epidemiology of Bladder Cancer and Prostate Cancer
Principal Investigators: Zuo-Feng Zhang
Additional researchers:
Institution: University of California in Los Angeles (UCLA)
Institution address:
UCLA Center for Environmental Genomics
UCLA School of Public Health
71-225 CHS, Box 951772
650 Charles Young Drive, South
Los Angeles, CA 90095-1772
310-825-8418 (Office)
Key References:
Cao W, et al. Cancer. 2005 Dec 1;104(11):2400-8.
Hung RJ, J Urol. 2006 Sep;176(3):1192-7.
Yang YC, et al. Br J Cancer. 2006 Dec 4;95(11):1455-8.
Study Design: Hospital-based Case-control
Matching factors: Un-matched
Country: U.S.A.
ICD-0-3 morphology codes: 81203, 81303, 80703, 81403
Follow up of cases? Yes
Expected time of follow-up? 60-120 months
Urinary Bladder ICD-0-3 morphology codes: Transitional cell carcinoma (81203); Papillary carcinoma (81303); Squamous cell carcinoma (80703); Adenocarcinoma (81403); Leiomyosarcoma (88903)
| Cases | Controls | |
|---|---|---|
| Years of enrollment | 1993-1997 | 1993-1997 |
| Source population | MSKCC, hospital | MSKCC, hospital |
| Response rate (enrolled/eligible) | 94.6% | 91.9% |
| Total number enrolled | 229 | 204 |
| Subjects with DNA | 170 | 158 |
| Ethnic origin | 97.1% Caucasian | 97.5% Caucasian |
| Age: mean (range) | 64.9 | 42.2 |
| Gender: % males | 82.9% | 76.6% |
| Questionnaire data | Cases | Controls |
|---|---|---|
| Demographics (age, sex, ethnicity, region, education etc..) | x | x |
| Active smoking | x | x |
| Passive smoking (only for non smokers-ex smokers) | x | x |
| Occupational exposures | x | x |
| Residential history | x | x |
| Water chlorination byproducts | - | - |
| Arsenic exposure | x | x |
| Other environmental exposures | x | x |
| Hair dye use (available after follow up) | x | x |
| Drug use (available after follow up) | - | - |
| Medical History (available after follow up) | x | x |
| Family History | x | x |
| Quality of life | - | - |
| Diet/nutrition | x | x |
| Caffeine intake | x | x |
| Fluid intake | x | x |
| Urine pH measurements | ||
| Other information, please specify (alcohol, tea, soft drinks; diuresis) | Alcohol, physical activities, pain relievers, etc | Alcohol, physical activities, pain relievers, etc |
| Biological Samples | Cases | Controls |
|---|---|---|
| Blood DNA | x | x |
| Buccal DNA | - | - |
| Serum/plasma | x | x |
| Cryopreserved whole blood / lymphocytes | - | - |
| Red blood cells | x | x |
| Urine samples | - | - |
| Toenail clippings | - | - |
| Others, please specify | - | - |
| Paraffin tissue blocks | - | |
| Frozen tissue | x |
| For Cases Only | |
| Information at time of diagnosis | Cases |
|---|---|
| Histological confirmation | x |
| Number of tumors (available after follow up) | x |
| Tumor site | x |
| Tumor size | x |
| Tumor grade | x |
| Growth pattern | - |
| Treatment of primary tumor | - |
| Stage | - |
| Other information, please specify | - |
| Follow-up information | Cases |
|---|---|
| Treatment information | - |
| Tumor recurrence | - |
| Tumor progression | - |
| Survival | x |
| Histological confirmation | - |
| Number of tumors | - |
| Tumor site | - |
| Tumor size | - |
| Tumor grade | - |
| Growth pattern | - |
| Stage | - |
| Active smoking | - |
| Occupational exposures | - |
| Drug use | - |
| Medical History | - |
| Quality of life | - |
| Caffeine intake | - |
| Fluid intake | - |
| Other information , please specify (as above) | - |